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Total 22718 results found since Jan 2013.

The functional vascular anatomy of the swine for research
CONCLUSIONS: Swine are utilized in broad-reaching fields for preclinical research. While many similarities between human and swine vasculature exist, there are important differences to consider when conducting and interpreting research. This review article highlights these differences and presents accompanying images to inform clinicians gaining experience in swine research.PMID:33813971 | DOI:10.1177/1708538121996500
Source: Vascular - April 5, 2021 Category: Surgery Authors: Joseph Edwards Hossam Abdou Neerav Patel Marta J Madurska Kelly Poe Janet E Bonin Michael J Richmond Todd E Rasmussen Jonathan J Morrison Source Type: research

Development of a Reproducible Swine Model of Chronic Ischemic Mitral Regurgitation: Lessons Learned.
CONCLUSION: A reproducible percutaneous model of severe IMR in swine is feasible with a guided anesthetic and peri-operative approach. This model can serve as a platform to better understand the mechanism of IMR and subsequently to test novel repair techniques. PMID: 32553769 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 14, 2020 Category: Cardiovascular & Thoracic Surgery Authors: Pasrija C, Quinn RW, Alkhatib H, Tran D, Bernstein D, Rice M, Kotloff E, Morales D, D'Ambra MN, Vesely M, Gammie JS Tags: Ann Thorac Surg Source Type: research

Effects of Metabolic Syndrome and SIRT1 Mutation on Store-Operated Ca < sup > 2+ < /sup > Entry in Peripheral Blood Mononuclear Cells in Ossabaw Miniature Swine
CONCLUSION: SIRT1L100P mutation is likely to require longer duration to manifest robust effects on PBMC SOCE that were found with MetS diet. PBMC activation and can be easily studied longitudinally in the SIRT1L100P mutant swine model due to the ease of blood sampling.PMID:35553311 | DOI:10.1096/fasebj.2022.36.S1.R6354
Source: Atherosclerosis - May 13, 2022 Category: Cardiology Authors: Aish Thamba Chris Royer Jason Collett James Byrd Mouhamad Alloosh Alex Coutts David Basile Michael Sturek Source Type: research

Endoscopic Fluorescence Angiography with Indocyanine Green : A Preclinical Study in the Swine.
CONCLUSION: Simultaneous visible color and ICG fluorescent imaging of the cortical vessels in the swine brain was satisfactory. Technical improvement and clinical implication are expected. PMID: 26819685 [PubMed]
Source: Journal of Korean Neurosurgical Society - January 30, 2016 Category: Neurosurgery Tags: J Korean Neurosurg Soc Source Type: research

Elucidation of Percutaneously Accessible Lymph Nodes in Swine: A Large Animal Model for Interventional Lymphatic Research
Conclusions The swine exhibits reproducible lymphatic anatomy with at least 4 percutaneously accessible lymph nodes/lymph node groups. Based on these results, the swine may be a suitable large animal model for research into lymphatic interventions.
Source: Journal of Vascular and Interventional Radiology - November 17, 2016 Category: Radiology Source Type: research

Quantitative angiographic anatomy of the renal arteries and adjacent aorta in the swine for preclinical studies of intravascular catheterization devices.
In conclusion, because of their similar dimensions to human, swine are an appropriate animal model for assessing the safety of, and determining optimal design of, catheter devices for RAs in simulated clinical use. However, there were species differences in the branching angle and adjacent aorta diameter, suggesting that swine models alone are inadequate to assess the delivery performance of catheter devices for RAs. PMID: 29353822 [PubMed - as supplied by publisher]
Source: Experimental Animals - January 23, 2018 Category: Research Tags: Exp Anim Source Type: research

Vitamin D attenuates HMGB1-mediated neointimal hyperplasia after percutaneous coronary intervention in swine.
In this study, we examined the association of vitamin D status with high mobility group box 1 (HMGB1)-mediated pathways (HMGB1, receptor for advanced glycation end products [RAGE], and Toll-like receptor-2 and -4 [TLR2 and TLR4]) in neointimal hyperplasia in atherosclerotic swine following bare metal stenting. Yucatan microswine fed with a high-cholesterol diet were stratified to receive vitamin D-deficient (VD-DEF), vitamin D-sufficient (VD-SUF), and vitamin D-supplemented (VD-SUP) diet. After 6 months, PTCA (percutaneous transluminal balloon angioplasty) followed by bare metal stent implantation was performed in the lef...
Source: Molecular and Cellular Biochemistry - July 31, 2020 Category: Biochemistry Authors: Satish M, Gunasekar P, Asensio JA, Agrawal DK Tags: Mol Cell Biochem Source Type: research

A reproducible swine model of a surgically created saccular thoracic aortic aneurysm.
We report a surgical method for creating a reproducible swine saccular TAA model.We used eight female swine weighing 20-25 kg (LWD; ternary species). All procedures were performed under general anesthesia and involved left thoracotomy. Following aortic cross-clamping, the thoracic aorta was surgically dissected and the media and intima were resected, and the dissection plane was extended by spreading the outer layer for aneurysmal space. Subsequently, only the adventitial layer of the aorta was sutured. At 2 weeks after these procedures, angiography and computed tomography (CT) were performed. After follow-up imaging, the ...
Source: Experimental Animals - February 12, 2021 Category: Research Tags: Exp Anim Source Type: research

Evaluation of an in vivo preclinical model for human middle meningeal artery embolization using the posterior intercostal artery of the swine
Conclusions This PIA model in swine could be used for research and development; objective benchmarking of agents, devices, and techniques; and in the training of neurointerventionalists.
Source: Journal of NeuroInterventional Surgery - August 17, 2023 Category: Neurosurgery Authors: Arturo Larco, J. L., Madhani, S. I., Liu, Y., Abbasi, M., Lylyk, P. N., Benike, A., Shahid, A., Tekin, B., Quinton, R., Savastano, L. E. Tags: Basic science Source Type: research

Epicardial Catheter Ablation Using High-Intensity Ultrasound: Validation in a Swine Model Original Articles
Conclusions— Compared with radiofrequency, HIU ablation in vivo demonstrates significantly deeper and larger lesions with greater epicardial sparing in a dose-dependent manner. Further development of this catheter may lead to a promising alternative to epicardial radiofrequency ablation.
Source: Circulation: Arrhythmia and Electrophysiology - December 15, 2015 Category: Cardiology Authors: Nazer, B., Salgaonkar, V., Diederich, C. J., Jones, P. D., Duggirala, S., Tanaka, Y., Ng, B., Sievers, R., Gerstenfeld, E. P. Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Animal Models of Human Disease, Translational Studies Original Articles Source Type: research

Mild coronary artery stenosis has no impact on cardiac and vascular parameters in miniature swine exposed to positive acceleration stress
Background: Exposure of pilots’ heart to acceleration-associated stress (+Gz stress) is an adverse effect of high-performance aviation. The occurrence of coronary heart diseases is one of the most frequent medical causes leading to cessation of flying. Aim: To assess the effects of +Gz stress on coronary artery stenosis (CAS) in a minimally invasive miniature swine model with a fast recovery. Methods: The proximal left anterior descending branch was ligated in 20 swine using silk suture. CAS degree (mild, moderate, severe) was analyzed by quantitative computerized angiography. Five swine underwent a sham operation. +Gz...
Source: Journal of Cardiovascular Medicine - September 2, 2016 Category: Cardiology Tags: Coronary artery disease Source Type: research

A novel swine model of subarachnoid hemorrhage-induced cerebral vasospasm
Conclusions: The relative scarcity of swine models for SAH-induced vasospasm motivated us to develop and quantify a straightforward protocol for producing consistent mild-to-moderate vasospasm following SAH. As swine is commonly used in translational cardiovascular research, we believe that this study constitutes an important phase in the study of SAH and in developing pharmacological agents and medical devices for interventions.
Source: Neurology India - September 6, 2017 Category: Neurology Authors: Zion Zibly Lory Fein Mayur Sharma Yaron Assaf Anton Wohl Sagi Harnof Source Type: research